Climbing Sensorimotor Skills in Lurcher Mutant Mice
Identifieur interne : 000124 ( Main/Exploration ); précédent : 000123; suivant : 000125Climbing Sensorimotor Skills in Lurcher Mutant Mice
Auteurs : S. Thifault [Canada] ; N. Girouard [Canada] ; R. Lalonde [Canada]Source :
- Brain Research Bulletin [ 0361-9230 ] ; 1996.
Abstract
Lurcher mutant mice, characterized by massive degeneration of cerebellar granule and Purkinje cells, were compared to normal mice of the same background strain in three sensorimotor learning tasks requiring climbing skills. In the coat-hanger test, Lurcher mutants were deficient in forepaw contact time and four paw latencies. Improvement over time was weak for both groups. For latencies before reaching the halfway point or the top of the diagonal bar in the same apparatus, Lurcher mutants showed gradual improvement while normal mice appeared to lose motivation to perform the task. In a rope-climbing test, a slight reduction in movement time was detected in Lurcher mutants with repeated trials, whereas the performance of normal mice was stable over time. In a water escape pole-climbing test, Lurcher mutants were impaired relative to controls. Both groups decreased the time required before grasping the pole across days of testing. The number of segments climbed was increased in Lurcher mutants across days. These results illustrate that massive cerebellar damage does not eliminate the possibility of acquiring climbing skills, but under some conditions limit performance. Copyright © 1996 Elsevier Science Inc.
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DOI: 10.1016/S0361-9230(96)00072-X
Affiliations:
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Thifault</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Hôtel-Dieu Hospital Research Center, Neurology Service, Neurobiology Unit, (Université de Montréal, Départements de Médecine et de Psychologie et Centre de Recherche en Sciences Neurologiques) , Montreal, Quebec, H2W 1T8</wicri:regionArea><wicri:noRegion>H2W 1T8</wicri:noRegion></affiliation></author><author><name sortKey="Girouard, N" sort="Girouard, N" uniqKey="Girouard N" first="N" last="Girouard">N. 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In the coat-hanger test, Lurcher mutants were deficient in forepaw contact time and four paw latencies. Improvement over time was weak for both groups. For latencies before reaching the halfway point or the top of the diagonal bar in the same apparatus, Lurcher mutants showed gradual improvement while normal mice appeared to lose motivation to perform the task. In a rope-climbing test, a slight reduction in movement time was detected in Lurcher mutants with repeated trials, whereas the performance of normal mice was stable over time. In a water escape pole-climbing test, Lurcher mutants were impaired relative to controls. Both groups decreased the time required before grasping the pole across days of testing. The number of segments climbed was increased in Lurcher mutants across days. These results illustrate that massive cerebellar damage does not eliminate the possibility of acquiring climbing skills, but under some conditions limit performance. Copyright © 1996 Elsevier Science Inc.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Thifault, S" sort="Thifault, S" uniqKey="Thifault S" first="S" last="Thifault">S. Thifault</name></noRegion><name sortKey="Girouard, N" sort="Girouard, N" uniqKey="Girouard N" first="N" last="Girouard">N. Girouard</name><name sortKey="Lalonde, R" sort="Lalonde, R" uniqKey="Lalonde R" first="R" last="Lalonde">R. Lalonde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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